Summer is over for Peter Parker and school's ready to start - both literally and in the real world of crime-fighting - as Spider-Man faces his first real challenge, the Enforcers, and his first real super-villain, Vulture.
Peter Parker attempts to tutor the popular Liz Allan while Spider-Man tries to stop Electro, who will stop at nothing to find a cure for the accident that made him who he is.
While Peter takes on the responsibility of helping Aunt May pay the bills while Montana, one of the Big Man's Enforcers, becomes the stunning Shocker to fulfill his responsibility: Eliminating Spider-Man.
Peter Parker and Mary Jane Watson go to the Midtown High Fall Formal. Meanwhile, the mysterious Green Goblin tries to force L. Thompson Lincoln to step down as NYC's Big Man of crime. Will Spider-Man be able to take on this new threat?
Peter and Spider-Man learn that their actions have consequences when Otto Octavius becomes the supervillain Doctor Octopus following a lab accident caused by the Green Goblin.
With Electro's help, Doctor Octopus breaks himself, Vulture, Shocker, Sandman, and Rhino out of prison to quench their mutual revenge on Spider-Man. Even with his new black suit, Spidey finds his old enemies are more than he can handle.
Spider-Man encounters master thief Black Cat and bonds with an alien symbiote, granting him enhanced abilities. Meanwhile, the Chameleon impersonates Spider-Man, forcing the real Spider-Man to join forces with Black Cat to stop him.
With May hospitalized and his friendship with Eddie ruined, Peter gains enough self-awareness to realize the symbiote is affecting his personality. The struggle between Peter and the symbiote evolves into a war within Peter's own mind.
As May is released from the hospital, Eddie, now transformed into the vicious Venom after bonding with the symbiote, seeks revenge on Peter by targeting his loved ones, including May and Gwen, drawing Spider-Man into motion to defeat him.
While Peter struggles to find the proper opportunity to talk to Gwen about their first kiss, Spider-Man must face a new supervillain, the self-proclaimed sorcerer Mysterio.
While Peter is conflicted over his choice to be with either Gwen or Liz, Kraven the Hunter comes to New York. After being defeated easily, Kraven enlists Professor Miles Warren to help transforming him into the "ultimate hunter".
Peter breaks up with Liz to be with Gwen, but she struggles to end her relationship with Harry. Meanwhile, Spider-Man attempts to solve the mystery of the Green Goblin's identity with Harry's help and has his final battle with the villain.
Nick talks about the trouble they had casting the Freddy Krueger sketch in an episode that features guest appearances by stand-up comedians Nick Kroll and Paul F. Tompkins.
Nick is happy to be working with Gay Robot again in an episode that features guest appearances by comedic actors Horatio Sanz, Kerri Kenney and Adam Scott.
Nick talks about how dirty the show can be in an episode that features guest stars SNL-alum Finesse Mitchell, rapper Swayze, and comedy duo Dana & Julia.
Nick talks about his obsession with scatological humor at an early age in an episode that features guest appearances from UCB co-founder Matt Walsh and comedic actor Bob Odenkirk.
Nick thinks his picture on the crew sweatshirts makes him look fat in an episode that features guest appearances by stand-up comedian Harland Williams and actor/performer Paul Scheer ("The League").
