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Frustrated with dating, Sam and Lizzie follow rules from "The Girl's Guide to Depravity" to navigate Chicago's singles scene, prioritizing self-protection over romance until unexpected love comes their way.

Best friends Lizzie and Sam both disappointed in love, prowl the nightclub scene together.

Lizzie and Sam head to a Mexican joint together on college night.

Sam breaks out the heavy artillery when her noisy neighbors interfere with her plans.

Sam deals with some tough competition for Richard, Lizzie conducts some undercover work.

Lizzie and Sam learn a new way to get what they want from men, which leads to a competition.

HD. 'The Bi-Guy Rule.' (Season One) The girls seek help from Tyler when Sam can't figure out if her hot new project partner is gay or not.

Sam and Danny have daytime sex. Lizzie reminds Sam not to date her sex buddy. Sam and Danny run into each other, and go to a movie and dinner. The next day he tells her he wants to keep sex and dating separate, and breaks up with her.

HD. 'The Cheating Rule.' (Season One) The girls decide to get even after witnessing what appears to be Kaylie's boyfriend hooking up.

Lizzie gets a call from Drew. It's not what it seems. Sam and Lizzie see a plain woman with a hunk, and go in search of the secret of a 'magic pussy' at tantra class and a Korean spa. Dirty Hot Guy shares his view.

HD. 'The Unavailable Rule.' (Season One) Lizzie and Sam get a surprise visit from the mentor Sienna who plans a phony bachelorette party.

HD. 'The Getting His Attention Rule.' (Season One) Sam begins to question 'the rules' after they land a visiting Sienna behind bars.

HD. 'The Pill Rule.' (Season One) Sam's first foray into mood-enhancing drugs leads to a bizarre night with Richard.

HD. 'The Revenge Rule.' In the Season One finale, the girls find themselves at a crossroads after an argument.

Sam spends the night with a classmate; Jason finds success with a new strategy.

HD. 'The Do Me Rule.' (Season Two) Jason tries to get Sam out of her Lizzie-less funk. Megan becomes a 'bad girl' to snag a 'bad boy.'

Lizzie's considering moving to Paris to be with her man, Laurent. Sam has a stable sweet relationship with her guy. Sam's neighbor, Megan tries too hard with her online date. Sam's old party girlfriend uses revenges sex against her ex.

HD. 'The Bar Sex Rule.' (Season Two) Sam makes a crazy bet with her womanizine co-worker; Jenna uncovers evidence of sexting on Ben's phone.

Sam attends a carpentry class where she meets a handsome guy, and goes for soup. Jason's boss Rachel gives him a hard time, but asks her intern to work late. Rachel's brother Charlie shows up

Sam is thinking about her decisions in life, and almost all of them were the 'no' kind. Now the girls are gonna change, saying yes or fucking yes to everything.

HD. 'The Hos Before Bros Rule.' (Season Two) Megan and Charlie finally give in to their attraction, to Sam's dismay.

Megan is rattled by her guilt; Tyler searches for a wife and Ben turns to Jenna.

Megan has an unforgettable dream; Sam makes a friend at a meeting.

HD. 'The Breakup Sex Rule.' (Season Two) Sam wants closure through breakup sex with Jason; Rachel and Jason bond over closing a big deal.