- Worked the cash register at Kevin Smith's comic book store. He later worked in construction before Clerks (1994) was made.
- Between the making of the two films Chasing Amy (1997) and Dogma (1999), Kevin Smith and Jason attended an AIDS benefit hosted by Harvey Weinstein, the chairman of Miramax. Upon learning that Mewes' mother was HIV-positive, Weinstein promised to get her to the best doctors in New York, a promise he kept.
- Arrested in Keansburg, New Jersey. He pleaded guilty to possession of a controlled dangerous substance (heroin). He was sentenced to 2 years probation, ordered to undergo substance abuse counseling, and submit to random urine testing. He was also fined $1000, had his drivers license suspended for 6 months, and was ordered to perform 200 hours of community service. (March 1999)
- Revealed that his character's full name in the View Askew films was Jason Derris, who is actually Rick Derris' little brother.
- Of Polish descent., he was born and raised in Highlands, New Jersey by a single mother where he graduated from Henry Hudson Regional High School in 1992. His mother, a drug addict, died in 2000 from AIDS.
- Married to Jordan Monsanto since January 30, 2009. She gave birth to their first child, a daughter named Logan Lee Mewes, on April 1, 2015 at Cedars-Sinai Medical Center in Los Angeles, California.
- Is Kevin Smith's first and only choice for the lead role of Oliver Queen in a proposed Smith written and directed "Green Arrow" upcoming film for The Weinstein Company.
- Close friend of Billie Joe Armstrong.
- Has appeared in seven films directed by Kevin Smith: Clerks (1994), Mallrats (1995), Chasing Amy (1997), Dogma (1999), Jay and Silent Bob Strike Back (2001), Clerks II (2006) and Zack and Miri Make a Porno (2008).
- Is a big fan of the TV shows Columbo (1971), Murder, She Wrote (1984), Buffy the Vampire Slayer (1997), Angel (1999) and Smallville (2001).
- His surname is pronounced "Me-youz".
- Rollerblades and plays hockey.
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