- He is from a very successful theatrical family. He is the son of Jon Pertwee, the first cousin, once removed, of Bill Pertwee, the younger brother of Dariel Pertwee, the nephew of Michael Pertwee and the grandson of Roland Pertwee.
- He is a popular voice-over artist.
- He has appeared twice in Poirot (1989) opposite David Suchet. In the episode 'The King of Clubs', Sean played the brother of Niamh Cusack. Years later he played in 'Dead Man's Folly' the son of 'Sinead Cusack'.
- Unlike his father, who was mostly known as a comic actor on stage, radio and in films, Pertwee took a different route into the profession and trained as a classical actor.
- Pertwee's first role was in Prick Up Your Ears (1987) starring Gary Oldman. Oldman played Jim Gordon in the Dark Knight Trilogy. Pertwee plays a role next to a new Jim Gordon in Gotham (2014).
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