- Has a son with Kirsten Dunst. Ennis Howard Plemons was born Thursday, May 3, 2018.
- He resembles Matt Damon and Philip Seymour Hoffman. He played a younger version of Damon's character in All the Pretty Horses (2000) and Hoffman's son in The Master (2012). Due to this resemblance he was also called "Meth Damon" during his role on Breaking Bad (2008) by the fanbase.
- The only main cast member of Friday Night Lights (2006) to have played football in real life.
- He is a great-great-great-great-great-grandson of early Texas settler Emily Margaret Brown Austin, the sister of Stephen F. Austin, known as the "Father of Texas," who colonized Texas in the early 1800s. The city of Austin is named after Stephen.
- Became engaged to Kirsten Dunst in January 2017, later confirmed to the public in the summer 2017.
- As of 2024, he has been in seven films that were nominated for the Best Picture Oscar: Bridge of Spies (2015), The Post (2017), Vice (2018), The Irishman (2019), Judas and the Black Messiah (2021), The Power of the Dog (2021) and Killers of the Flower Moon (2023).
- Was considered by J.J. Abrams for the lead in Star Wars: Episode VII - The Force Awakens (2015) which went to John Boyega.
- Inducted into the Texas Film Hall of Fame in Austin, Texas in March 2016.
- Close friends with his Friday Night Lights (2006) costars Taylor Kitsch, Zach Gilford, and Kyle Chandler.
- Aside from acting Plemons also sang in the alternative folk-rock band Cowboy and Indian together with Daniel James and Jazz Mills.
- Attended acting classes at Dallas Young Actors Studio in Dallas, Texas.
- He is of English, and some Scottish, Scots-Irish/Northern Irish, and Swiss-German, ancestry.
- In Cold Case (2003) (The Long Blue Line (2009) and Into the Blue (2009)), he played a military cadet nicknamed Rihanna. Years later, he starred in Battleship (2012) with Rihanna herself.
- Invited to join the actor's branch of AMPAS in 2022.
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