- He is best remembered for playing Boy, the adopted son of Johnny Weissmuller's Tarzan in eight Tarzan movies, and for his role as Bomba the Jungle Boy in a dozen low-budget Monogram features.
- Johnny and his brother Billy Sheffield were both in Knute Rockne All American (1940), playing Knute Rockne at different ages.
- Suffered his fatal heart attack on October 15, 2010 at his home four hours after he fell off a ladder while pruning a palm tree. His brother Billy Sheffield died two months later.
- By 1947, his role as "Boy", Tarzan's adopted son, in the Johnny Weissmuller Tarzan films at MGM came to an end as he had literally outgrown the role. Several years later, when he began a series of films as "Bomba" for Monogram, he was almost six feet tall.
- The only actor to play Tarzan's adopted son in more than one theatrical motion picture.
- Not to be confused with older character actor John Sheffield, whose career was comprised with uncredited bit parts over almost the same span of years.
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