- Both Sophie and her sister, Emma Thompson, met their future husbands--Richard Lumsden and Greg Wise respectively--on the set of Sense and Sensibility (1995).
- She was awarded the 1999 Laurence Olivier Theatre Award for Best Actress in a Musical for her performance in "Into the Woods".
- Younger sister of Emma Thompson. Consequently she is the sister-in-law of Greg Wise and the former sister-in-law of Kenneth Branagh.
- Daughter of stage director Eric Thompson and Phyllida Law.
- She and her sister Emma Thompson, as well as her former brother-in-law Kenneth Branagh, have all appeared in the Harry Potter films. Also appearing is Helena Bonham Carter, who played Emma's sister in Howards End (1992).
- Won the WhatsonStage supporting actress award for "Present Laughter.".
- Gave birth to her first child at age 35: a son, Ernie James Lumsden, in February 1997. Child's father is her ex-husband, Richard Lumsden.
- Gave birth to her second child at age 38: a son, Walter Ernest Thompson, in October 2000. Child's father is her ex-husband, Richard Lumsden.
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