- Tearfully admitted on The Talk (2010) that after many years of trying, she and her husband Jeff Tietjens have stopped trying to conceive a child.
- Graduated from Dartmouth College with a degree in political science and a minor in environmental policy.
- She is of both African American and Native American descent.
- Her parents divorced when she was 10, and she and her sister, Feri Tyler, were raised by their father, Jim Tyler.
- Is a stand-up comic.
- Also plays on the World Poker Tour in the Hollywood Home games for the Childhelp USA charity.
- Appeared in the music video for the song "Tacky" by 'Weird Al' Yankovic.
- Attended high school in San Francisco with Sam Rockwell.
- She is a regular contributor to Glamour and Jane magazines.
- Has her own podcast called "Girl on Guy With Aisha Tyler" and regularly invites comedian friends to be guests.
- Minored in environmental policy at Dartmouth College. A fellow Dartmouth student was Connie Britton.
- Was raised in a strictly veggie home.
- Moved to Los Angeles from her native San Francisco in 1996.
- Worked with Scott Rockett while performing at the Laugh Factory in Hollywood. They also were both working at E! Entertainment Television at the same time; she was the the host of Talk Soup (1991), and he was a producer on True Hollywood Story (1996).
- Named #72 on the Maxim magazine "Hot 100 of 2005" list.
- Was featured as #61 in Maxim Magazine's "Hot 100 of 2002" supplement. (2002)
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