- Wedgeworth joined the seasoned cast of Three's Company (1976) in 1979 as bosomy neighbor-divorcée Lana Shields, who had strict and assertive designs on John Ritter's Jack Tripper character. She was eventually written out of the series mid-season with no explanation given in the story for Lana's disappearance. Later, Wedgeworth revealed that she wasn't fired but asked to be let go. After shooting a couple of episodes of the show, Wedgeworth said, some of the cast members were complaining about the size of her part and the character dwindled down to practically nothing. Wedgeworth asked the producers to write the part of Lana back to the way it was intended or release her.
- Childhood friends with actress Jayne Mansfield.
- Attended high school in Dallas with Jayne Mansfield.
- Over fifteen years after their divorce, she appeared with ex-husband Rip Torn in the film Birch Interval (1976). By this time, he was married to actress Geraldine Page.
- Was a long time resident of New York City, and although much of her work was in Los Angeles, she did have a fear of flying.
- Won Broadway's 1978 Tony Award as Best Actress (Featured Role - Play) for "Chapter Two."
- She was awarded the 1978 Antoinette Perry (Tony) Award for Best Featured Actress in a Play for "Chapter Two," on Broadway in New York City.
- Won a Drama Desk Award for her role in "A Lie of the Mind" (1986).
- Attended The University of Texas at Austin (graduated 1957).
- Wedgeworth (Lana Shields) had the shortest run on Three's Company (1976) in the 1979-1980 season.
- On "Three's Company", in the first scene of her first episode, she spills liquor on John Ritter, and in her last scene of her last episode, she again pours liquor on Ritter.
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