- He is deaf in his right ear, from a virus as an infant.
- 2011: Lowe told USA Today that if he did not dye his hair, it would be entirely grey. He said he went grey at age 24.
- First met Sheryl Berkoff on a blind date in 1983. They met again in 1989 while Rob was filming Bad Influence (1990) and eventually got married two years later.
- Lost out for the role of Caledon Hockley in Titanic (1997), which went to Billy Zane.
- Was one of the nine original members of the 1980s "brat pack", along with Judd Nelson, Demi Moore, Anthony Michael Hall, Sean Penn, Ally Sheedy, Molly Ringwald, Emilio Estevez and Andrew McCarthy.
- On the television show, Who Do You Think You Are? (2010), he found out some interesting things about his mother's family. There was an application for admittance into the "Daughters of the American Revolution" from someone in Rob's family because of his five times great-grandfather, John Christopher East. However, the application was denied because there was no proof that he fought in the Revolutionary War. Rob uncovered that John Christopher East (or Johan Christoph Oeste in German) was a Hessian soldier who fought for the British in the Battle of Trenton and was captured by George Washington. John Christopher East settled in the United States rather than return to Germany. While doing some digging, there was a record of John Christopher East on the side of the United States so the DAR accepted Rob's ancestor as a patriot. Consequently, the "Sons of the American Revolution" invited Rob to become a member. Rob found it very interesting that his ancestor actually fought on both sides of the war.
- During his teenage years, he was very good friends with Emilio Estevez and Charlie Sheen.
- Mike Myers is known to have resurrected Rob's acting career. He and Rob became close friends while filming Wayne's World (1992). Myers gave him an unbilled role in Austin Powers: International Man of Mystery (1997) (although the scene was deleted in editing) and gave him a role as the young Number Two in Austin Powers: The Spy Who Shagged Me (1999).
- He was considered for the role of Dr. Derek Shepard in Grey's Anatomy (2005), which went to Patrick Dempsey.
- 2003: Helped in the election of Arnold Schwarzenegger as Governor of California.
- He appeared in David Foster's music video "Love Theme from St. Elmo's Fire (Instrumental)" as the Sax Player.
- In his book "Love Life", Rob Lowe tells a story about the filming of his series, The Lyon's Den (2003), to illustrate what he sees, in hindsight, as the studio's indifference to the show. Lowe says that to save money on the production, the main sets were constructed in an abandoned paint factory in the San Fernando Valley (instead of in a conventional soundstage on a studio lot in a more central location). The air-conditioning system in the ex-factory was faulty and, on hot days when it failed, crew members would often faint from the residual paint fumes. Furthermore, the building was next-door to a dildo factory (the San Fernando Valley is the capital of the U.S. porn and sex-toy industries). Lowe remembered that the same day they were told that the show was canceled (but they would still have to continue filming all 13 episodes for the overseas and DVD markets), there were wildfires in the Valley. The dildo factory was evacuated but the cast and crew of "The Lyon's Den" was not allowed to do the same.
- Has the dubious distinction of having left a successful television series (The West Wing (1999)), to having two failed television series within a year (The Lyon's Den (2003) and Dr. Vegas (2004)), both of which were canceled before running their full seasons. He also rejected the role of Dr. Derek Shepard on Grey's Anatomy (2005) (a series which was still running ten seasons after it premiered) in favor of his role on "The Lyon's Den", which was canceled after six episodes.
- Impersonated Robert Wagner's voice for the young Number Two in Austin Powers: The Spy Who Shagged Me (1999).
- One of the select few to be nominated for and subsequently "win" a Razzie Award and then not get another nomination again. Lowe "won" the 1986 Worst Supporting Actor Razzie for his performance in St. Elmo's Fire (1985).
- He was awarded a Star on the Hollywood Walk of Fame for Television at 6667 Hollywood Boulevard in Hollywood, California on December 8, 2015.
- His wife, Sheryl Berkoff, is a make-up artist.
- Older brother of actor Chad Lowe and older half-brother of Micah Dyer.
- He appeared in John Parr's music video "St. Elmo's Fire (Man In Motion)".
- 2000: Voted one of People magazine's 50 Most Beautiful People in the World.
- His parents were both of over half German ancestry. He also has a smaller amount of English, Irish, Scottish and Welsh, roots.
- Did a failed audition for Footloose (1984).
- In 2015, he launched an online men's skincare line branded as PROFILE(TM) Men's Facial Products.
- Appeared on the cover of the final issue of John Kennedy Jr.'s magazine "George" (September 1999), shortly after Kennedy's death in a private plane crash.
- Former brother-in-law of Oscar-winning actress Hilary Swank.
- Is only 7½ years younger than Bo Derek, who played his "mom" in Tommy Boy (1995).
- Auditioned unsuccessfully for the role of John Bender in The Breakfast Club (1985), which went to Judd Nelson.
- Listed as one of twelve "Promising New Actors of 1984" in John Willis' Screen World, Vol. 36.
- 2009: Sold his six-bedroom house in Montecito, California for $7.6 million.
- Has a younger brother, Justin W. Lowe, from his father's second marriage.
- Brother-in-law of Kim Painter.
- In his mid-20s, the tabloids linked him with older women including Jane Fonda and Madonna.
- A former paperboy.
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