Trivia

Told that the script for Legally Blonde (2001) initially came her way but she was leery about taking on another "dumb blonde" role since Married with Children (1987) had just wrapped. The role eventually went to Reese Witherspoon and she was nominated for the Golden Globe for portraying Elle Woods. Applegate is happy with the way things turned out and said that Witherspoon did a much better job than she ever could.

Her garage was the birthplace of The Pussycat Dolls.

In contrast to her character on Married with Children (1987), she has been described by her co-stars on the sitcom as an intelligent, versatile and talented actress. In multiple interviews, Ed O'Neill stated that only someone of her caliber and intelligence could pull off the "dumb blonde" character on the sitcom so convincingly, and that she would often nail her performance on the first or second take.

People magazine reported that she had been diagnosed with early-stage breast cancer. Benefiting from early detection through a doctor-ordered MRI, the cancer was not life-threatening. She is following the recommended treatment of her doctors and will have a full recovery. On 19 August 2008, it was announced that she was cancer-free after a double mastectomy, though cancer was found in only one breast. (August 3, 2008)

She and Bruce Willis are the only two actors to have guest-starred on Friends (1994) and win an Emmy Award for their performance.

Last year, Applegate discussed how her life had been impacted since her MS diagnosis, explaining she had seen a 40-lb. weight gain and now struggles to walk without the support of a cane. (May 5, 2023)

Attended high school with Milla Jovovich.

Was at the Viper Room the night River Phoenix collapsed on the sidewalk outside the club. She witnessed the seizure induced by a drug Phoenix had in his system and later re-enacted the seizure at an anti-drugs dance piece.

She was awarded a star on the Hollywood Walk of Fame for Television at 7007 Hollywood Boulevard in Hollywood, California. Her co-star Ed O'Neill was a guest speaker at the ceremony. Her Walk of Fame star is located across the street from the Hollywood Roosevelt Hotel. (November 14, 2022)

Revealed that she had been diagnosed with multiple sclerosis several months earlier. (August 2021)

Has one daughter with her husband Martyn LeNoble: Sadie Grace LeNoble (b. 1/27/11 at Cedars-Sinai Hospital in Los Angeles, CA).

Grew up near the site of the notorious 1981 Wonderland (or Four-on-the-Floor) murders involving John Holmes. She later played Susan Launius, the sole survivor of the murders, in the movie Wonderland (2003).

Co-wrote "The Penis Song" with The Sweetest Thing (2002) co-stars Cameron Diaz and Selma Blair.

First appeared on television as an infant in a commercial for disposable diapers.

Passed the GED with flying colors toward the end of her junior year.

Is referenced in Donnie Darko (2001) by Jake Gyllenhaal's character while visiting the psychiatrist.

Was referenced in the song "Set Adrift on Memory Bliss" by the hip-hop group PM Dawn.

Was hired by Jodie Foster to star as Paula Olsen in Nell (1994) but was dismissed after Foster was replaced by Michael Apted as director. Applegate was replaced by Natasha Richardson.

Auditioned for the role of Samantha Micelli on Who's the Boss? (1984), which went to Alyssa Milano.

Her love of the video game Guitar Hero (2005) gave her a two-week migraine headache. She had to go to the doctor for treatment of the headache, taking time away from her television series. She has not played the game since 15 April 2009.

Had her ovaries and fallopian tubes removed to prevent ovarian cancer. (October 2017)

Her mother wrote a song for her. She also sang the song, called "Christina's World".

Returned to work four months after giving birth to daughter Sadie in order to begin filming Up All Night (2011).

Married longtime boyfriend Johnathon Schaech on 10/20/01, in a small Palm Springs (CA) ceremony, attended by immediate family and friends.

Her personal manager for over 26 years was Tami Lynn, who was also her co-producing partner on her sitcom Jesse (1998).

Has three cats and a turtle named Tibbell.

Paid tribute to the late Elizabeth Taylor via Twitter, stating that Taylor's film Who's Afraid of Virginia Woolf? (1966) is her favorite movie and Taylor's portrayal of Martha is her favorite movie performance. (March 23, 2011)

Daughter of Robert Applegate and Nancy Priddy. Her ancestry includes English, Scottish, German, Irish, Scots-Irish (Northern Irish), Welsh, Dutch, French, Danish, Swedish, and remote Norwegian.

Nominated in the Outstanding Actress in a Comedy Series, Up All Night (2011), at The Women's Image Network (WIN) Awards. (2012)

Finds Al Green's song "Simply Beautiful" one of the sexiest songs she has ever heard.

Supports People for the Ethical Treatment of Animals (PETA).

Chosen by People magazine as one of the 100 Most Beautiful People in the World. (2009)

She is one of four actors from Hall Pass (2011) to become a first-time parent the same year the film was released, along with her co-stars Owen Wilson, Jenna Fischer and Alyssa Milano.

While on stage in Chicago in the Broadway-bound revival of the musical "Sweet Charity" (1966), she broke a bone in her right foot. On 25 March, in Boston with Charlotte d'Amboise in the titular role, its producers officially canceled the production, announcing it would close after its last regularly scheduled tryout performance, the 27 March matinee. On 29 March, the production was officially resurrected with a revised Broadway preview and opening schedule. Although Ms. d'Amboise continued in the lead role for the first week of Broadway previews, on 18 April Applegate made her Broadway debut as Charity Hope Valentine. On 4 May, the second Broadway revival of "Sweet Charity" opened officially with Applegate as its star. She was nominated for a 2005 Tony Award for Best Actress in a Musical. (March 11, 2005)

Met her ex-husband, Johnathon Schaech, through director Gregg Araki.

Chosen by People magazine as one of the 50 Most Beautiful People in the World. (1999)

In an interview on Late Night with Conan O'Brien (1993), she mentioned that though she has green eyes on one magazine cover picture, her eyes were changed to blue.

Became engaged to Martyn LeNoble, having been in a relationship with him since July 2008, after he proposed to her on a beach in Palm Springs, California. (February 14, 2010)

Has a half-brother and a half-sister from the subsequent marriage of her father, Robert Applegate, after he and Christina's mother, Nancy Priddy, divorced.