- Her character Rebecca Howe is the only regular character from Cheers (1982) - with the exception of Coach Ernie Pantusso (Nicholas Colasanto) - not to guest star on Frasier (1993).
- Shared an apartment with Mimi Rogers while they first began their careers.
- Her first husband Robert Alley was a distant relative who shared the same last name.
- In 1981, her father was seriously injured, and her mother was killed in an automobile accident caused by a drunk driver.
- Had her own Star Trek action figure made in her likeness from the movie Star Trek II: The Wrath of Khan (1982).
- She was awarded the 1983 Drama Logue Award for Outstanding Performance for "Cat on a Hot Tin Roof" at the Mark Taper Forum Theatre in Los Angeles, California.
- In May 2000, she purchased the former home of Lisa Marie Presley, a 5,200-sq-ft. waterfront mansion in Clearwater, Florida for $1.5 million.
- Has appeared on Match Game PM (1975) in 1979, where she won $6,000. Identified herself as an interior designer who was in Los Angeles, California from Wichita, Kansas, on a job assignment. Then, in 1980, she was a contestant on Password Plus (1979), but took home only $800.
- Suffered from a fear of flying.
- Was John Travolta's best female friend and close friends with Oprah Winfrey.
- From 1991 - 2020, she owned a 21-bedroom summer house in Islesboro, Maine -- the Mitchell Cottage, formerly the Islesboro Inn.
- Was a huge fan of Star Trek (1966). Her career breakthrough came when she landed her movie debut as Lieutenant Saavik in Star Trek II: The Wrath of Khan (1982).
- Looked after John Travolta and Kelly Preston's daughter Ella Bleu Travolta at the time of the birth of their son Benjamin; was subsequently the first celebrity friend to see the new arrival.
- Opened a literacy and tutoring center in her hometown of Wichita, Kansas called Lillie's Learning Place, named after her daughter.
- She was awarded a Star on the Hollywood Walk of Fame at 7000 Hollywood Boulevard in Hollywood, California on November 9, 1995.
- Had a miscarriage, when she expected her first child with husband Parker Stevenson. (September 1990)
- Attended drama classes at Kansas State University in Manhattan, Kansas, but dropped out after her sophomore year. She moved to Los Angeles, California to pursue Scientology and work as an interior designer.
- When she appeared on Password Plus (1979), she was partnered with Dick Martin. When she appeared on Match Game PM (1975), Martin was one of the six celebrity panelists.
- In May 2022, Alley was diagnosed with stage IV colon cancer following a doctor's visit for a sore back. She underwent chemotherapy treatment at the Moffitt Cancer Center in Tampa, Florida. Despite on the treatment, she died on December 5, 2022 at her home in Clearwater at the age of 71.
- Was briefly engaged to actor James Wilder.
- Attended and graduated from Wichita Southeast High School (1969). Former high school cheerleader.
- Upon her death, she was immediately cremated, and her ashes were returned unto the possession of her surviving family.
- Competed during the 12th and 15th seasons of ABC's Dancing with the Stars (2005).
- Gave an excellent performance as the obsessive, driven Virgilia Hazard on the miniseries North and South (1985).
- Born to Lillian Maxine (Heaton) and lumber business owner Robert Deal Alley. Her grandparents hailed from Nebraska and Illinois.
- Is the second regular cast member of Cheers (1982) to pass away, after Nicholas Colasanto on February 12, 1985 (before the sitcom had completed its third season).
- Is the third female celebrity Scientologist to pass away, after Karen Black on August 8, 2013, and Kelly Preston on July 12, 2020. All three died of cancer.
- She had English, German, Scottish and Irish ancestry.
- While working with Jenny Craig, she had lost 75 pounds bringing her weight down to 145 pounds. After parting ways with Jenny Craig, she gained 83 pounds and weighed as much as 228 pounds.
- Celebrity spokesperson for Pier 1 Imports, Inc. (2000 - 2004) and for Jenny Craig, Inc. (2004 - 2007).
- Father owned a lumber company.
- She adopted her daughter Lillie.
- Was a huge fan of both Prince and Jamie Foxx.
- In 2007, she gave $5 million to the Church of Scientology, and in 2010, placed her home in Encino, California on the market for $6.5 million.
- Endorsed Donald Trump as Republican candidate for the 2016 United States presidential election. Endorsed John James as Republican candidate for the 2020 United States Senate election in Michigan.
- Former sister-in-law of Hutch Parker and Rebecca Pollack.
- She has appeared in one film that has been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Star Trek II: The Wrath of Khan (1982).
- Used to live in a farmhouse at Isleboro, Maine.
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