- She was supposed to play Bobbie Markowitz in The Stepford Wives (2004). When her father became sick, both she and her brother John Cusack had to drop out of the film. Bette Midler then got the role.
- In 2003, both Joan and her brother John Cusack signed the "Not in My Name" resolution (along with people such as Noam Chomsky and Susan Sarandon) opposing the invasion of Iraq.
- Cusack was the first regular cast member of Saturday Night Live (1975) (1985-1986 season) to be nominated for an Academy Award. She was nominated for Best Supporting Actress for her work in Working Girl (1988).
- One of her conditions for starring in the sitcom What About Joan (2000) was that it had to be produced in Chicago so she would not have to leave her family.
- Husband, Dick Burke, is a Chicago attorney.
- In the mid-1980s, she was a co-founder of the three woman improv comedy troupe, "An Impulsive Thing", with Bonnie Hunt and Holly Wortell.
- She and Julianne Moore played pregnant women in Nine Months (1995). In 1997, their own sons were born.
- In the film In & Out (1997), where Joan stars alongside Kevin Kline, there is a group dance scene on the song "Macho Man" by The Village People. Years earlier, in Addams Family Values (1993), Joan sings the same song.
- Shares her birthday (October 11) with Michelle Trachtenberg, her on-screen daughter in Disney's Ice Princess (2005).
- First son, Dylan John Burke, born. (June 17, 1997)
- Graduated from the University of Wisconsin at Madison with a degree in English in 1984.
- Second son, Miles Burke, born. (July 2000)
- She was nominated for a 1991 Joseph Jefferson Award for Actress in a Supporting Role in a Play for "A Midsummer's Night Dream" at the Goodman Theatre in Chicago, Illinois.
- Has appeared with her brother John Cusack in ten films: Class (1983), Sixteen Candles (1984), Grandview, U.S.A. (1984), Broadcast News (1987), Say Anything... (1989), Grosse Pointe Blank (1997), Cradle Will Rock (1999), High Fidelity (2000), Martian Child (2007) and War, Inc. (2008).
- Both she and Matt Dillon were in their debut film, My Bodyguard (1980), as classmates. 17 years later, they both had roles in the film In & Out (1997), but this time she was his former teacher.
- Has appeared with Alec Baldwin in four films: Married to the Mob (1988), Working Girl (1988), The Last Shot (2004) and My Sister's Keeper (2009).
- Has appeared with Whoopi Goldberg in four films: Corrina, Corrina (1994), In & Out (1997), It's a Very Merry Muppet Christmas Movie (2002) and Toy Story 3 (2010).
- Has appeared in five films each with the word "Toy": Toys (1992), Toys in the Attic (2009), Toy Story 2 (1999), Toy Story 3 (2010) and Toy Story 4 (2019).
- Born at 11:00am-EDT.
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