- Her Best Supporting Actress Oscar statuette was stolen from her home kitchen in 1989. The burglar left only her nameplate.
- Worked as a physical therapist in the 1950s in order to earn enough to train as an actress.
- She was awarded a Star on the Hollywood Walk of Fame for Live Theater at 6233 Hollywood Boulevard in Hollywood, California on May 24, 2013.
- Cousin of 1988 Democratic US presidential candidate Michael Dukakis. She gave him a shout-out when winning her Oscar in the spring of that year.
- Sister of actor Apollo Dukakis.
- Daughter of Greek immigrants Constantine "Costa" (1899-1975) and Alexandra "Alec" (née Christos) Dukakis (1901-1994).
- Attended and graduated from Arlington High School in Arlington, Massachusetts.
- Grandmother of Isabella, Sofia, Luka and Erlinda.
- Returned to work six months after giving birth to her daughter Christina Zorich to begin performing on stage in "The Rose Tattoo".
- Her favorite actress was Geraldine Page.
- Before her death, she had never retired from acting.
- Was three months pregnant with her daughter Christina Zorich when she completed her run of the off-Broadway play "Electra".
- Gave birth to her 1st child at age 33, a daughter Christina Zorich on February 28, 1965. Child's father is her husband, Louis Zorich.
- Gave birth to her 2nd child at age 37, a son Peter Zorich on September 19, 1968. Child's father is her husband, Louis Zorich.
- Studied acting with Peter Kass in Boston, and teaches master classes at studios and universities around the world.
- Gave birth to her 3rd child at age 39, a son Stefan Zorich on February 4, 1971. Child's father is her husband, Louis Zorich.
- In 1949, she underwent a nose job to remove a bump at the bridge of her nose.
- Was the 95th actress to receive an Academy Award; she won a Best Supporting Actress Oscar for Moonstruck (1987) at 60th Annual Academy Awards (1988) on April 11, 1988.
- She and Anita Gillette had the same on-screen love interest twice: Larry Haines on Search for Tomorrow (1951) and Vincent Gardenia in Moonstruck (1987).
- Has four grandchildren.
- Is one of 25 actresses to have won an Academy Award for their performance in a comedy; hers being for Moonstruck (1987). The others, in chronological order, are: Claudette Colbert (It Happened One Night (1934)), Loretta Young (The Farmer's Daughter (1947)), Josephine Hull (Harvey (1950)), Judy Holliday (Born Yesterday (1950)), Audrey Hepburn (Roman Holiday (1953)), Goldie Hawn (Cactus Flower (1969)), Glenda Jackson (A Touch of Class (1973)), Lee Grant (Shampoo (1975)), Diane Keaton (Annie Hall (1977)), Maggie Smith (California Suite (1978)), Mary Steenburgen (Melvin and Howard (1980)), Jessica Lange (Tootsie (1982)), Cher (Moonstruck (1987)), Jessica Tandy (Driving Miss Daisy (1989)), Mercedes Ruehl (The Fisher King (1991)), Dianne Wiest (Bullets Over Broadway (1994)), Marisa Tomei (My Cousin Vinny (1992)), Mira Sorvino (Mighty Aphrodite (1995)), Frances McDormand (Fargo (1996)), Helen Hunt (As Good as It Gets (1997)), Judi Dench (Shakespeare in Love (1998)), Gwyneth Paltrow (Shakespeare in Love (1998)), Penélope Cruz (Vicky Cristina Barcelona (2008)), and Jennifer Lawrence (Silver Linings Playbook (2012)).
- Born on the exact same date as actor James Tolkan.
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