- He first became a fan of Deadpool when he found a comic where Deadpool describes himself as looking like "Ryan Reynolds crossed with a Shar-Pei".
- Failed his high-school drama class due to non-attendance.
- In November 2008, he ran in the New York City Marathon on behalf of the Michael J. Fox Foundation. His father was diagnosed with Parkinson's disease in 1995.
- When his first daughter was born, a good friend of his (whom he described as close enough to him to be there when the baby was born), tried to sell pictures of her to a tabloid magazine. A furious Reynolds confronted the friend, confirmed the story was true, then told him that their friendship was destroyed and they would never see or speak to each other ever again. The tabloid did not use the pictures because it would have left them open to a massive invasion of privacy lawsuit.
- Has a fear of flying since he once went skydiving and his parachute failed to open at the first attempt.
- Gained 25 pounds of muscle for his role as Hannibal King in Blade: Trinity (2004).
- On April 12, 2015, he was involved in a hit-and-run incident between filming of Deadpool (2016) in Canada. While walking through a parking garage, he was struck by the car of a paparazzo who then fled the scene. Reynolds sustained only minor injuries and later joked about the incident on Twitter.
- He did not enjoy working on Green Lantern (2011). He admits to having a poor working relationship with director Martin Campbell. He has also said that the film's critical and financial failure was a huge relief because he didn't want to play Hal Jordan again.
- Is the youngest of four brothers. Two of his brothers are policemen. His paternal grandfather, Chester "Ches" Reynolds, was a Canadian politician and member of the Social Credit Party of Alberta. Chester was an MLA in Alberta from 1940 to 1944.
- On Halloween 2015, he went Trick-or-Treating with children as the character Deadpool, promoting his role as the title character in Deadpool (2016).
- Has expressed great interest in portraying the DC Comics character The Flash if Warner Bros. should ever decide to do a film adaptation of the comic book.
- Married fiancée Scarlett Johansson in a private Canadian ceremony on September 27, 2008.
- In 2002, he badly injured his back jumping from a bridge in Zurich, Switzerland.
- One of the few actors to star in films based on comic books from both the Marvel Comics (X-Men Origins: Wolverine (2009) and the Deadpool (2016)) and DC Comics (Green Lantern (2011)) catalogs.
- Turned down the role of Xander Harris on Buffy the Vampire Slayer (1997), which went to Nicholas Brendon, reportedly for his own unpleasant high-school experiences. Star Sarah Michelle Gellar refused to believe this when she was told during a "Buffy" trivia quiz promoted by SheKnows.com.
- Became engaged to his girlfriend of two years, Canadian singer Alanis Morissette in June 2004; in June 2006 they announced that their engagement was off.
- He was awarded a star on Canada's Walk of Fame in Toronto, Ontario in 2014.
- In early 2001, he met actress Rachael Leigh Cook and the two immediately hit it off. However, Rachael had to fly to Britain shortly after to film Blow Dry (2001). Ryan ended up surprising her, pulling out of his filming schedule, and following her all the way to London. It was a success and they ended up dating for a year.
- Was named the "Sexiest Man Alive" by People magazine during the same time that his wife Scarlett Johansson was named as "Babe of the Year" by GQ magazine. (2010)
- He was awarded a Star on the Hollywood Walk of Fame at 6801 Hollywood Boulevard in Hollywood, California on December 15, 2016. Actress-singer Anna Faris was one of the guest speakers at the ceremony.
- Can do a standing back flip.
- He was traveling in Indonesia with his former fiancée, Alanis Morissette, when the tsunami struck. They were uninjured since they were staying on the opposite end of the island from where the tsunami hit.
- Co-owns, with fellow actor Rob McElhenney, the Welsh football team Wrexham, which they bought in 2020.
- While T-Mobile recently purchased Mint Mobile, Ryan still maintains creative control over the company's advertising agency with his reported 25% stake in the company.
- On May 12, 2018, Reynolds attended a Fußball-Bundesliga match between Hertha BSC and RB Leipzig while promoting Deadpool 2 (2018) in Berlin, Germany. Talking to sports journalist Jens Westen of Sky Germany before the game, Reynolds revealed that he was an avid soccer player from age 6 to 16. He said while he played with much ambition, he had to realize early on that he would never be good enough to pursue a career as a professional athlete.
- Can speak English and French and knows some conversational Italian, Spanish and Irish.
- Merited a place in Time magazine's "100 Most Influential People" issue with an homage written by Dame Helen Mirren. (May 2017)
- Used to work in a grocery store.
- Received a Youth in Film Award nomination for Best Actor for his work on Nickelodeon's teen drama Hillside (1990).
- Lives in the ultra-trendy Los Angeles neighborhood of Los Feliz. Giovanni Ribisi, Bo Barrett, Scarlett Johansson, Chris Pine, Brad Pitt, Mark Ruffalo, Kristen Stuart, Michael Cera, Robert Pattinson, and Hannah Telle are among the other actors who also call Los Feliz home.
- Ryan Reynolds played Seth in Sabrina the Teenage Witch (1996) where he made mention of the show in the movie Deadpool 2 (2018). Producer and Author Mike Sims is a huge fan of the Deadpool movies and works with a writer of Sabrina the Teenage Witch (1996), Barney Cohen on the television pitch The Lazarus Game.
- Is a huge fan of the Green Bay Packers.
- His ancestry is Irish, Scottish, one-eighth Luxembourgish (from Luxembourg), English, Cornish, and more distant Dutch and German. Some of his forebears were American-born, including his paternal grandfather, who was born in Chicago to a Canadian father from Peterborough and an American (Irish-American) mother from New Orleans. His paternal grandmother was born in Kansas. His maternal grandfather, Neil Alexander Stewart, was a prominent doctor.
- On the television series episode If These Walls Could Talk (1995), he played a ghost trapped in a haunted house. Ironically, in The Amityville Horror (2005), he plays a living man trapped in a haunted house.
- When he was a toddler, a newspaper gave out his address for no apparent reason, accompanying a photo of him at the local pool.
- Attended high school with Joshua Jackson in Vancouver, Canada.
- Ryan alleges that he and Paul Anka are friends and get together occasionally.
- Often is in a feud with Hugh Jackman.
- Attended Kwantlen College for a few months before leaving to pursue his acting career.
- Is the only actor to appear in all 65 episodes of Hillside (1990).
- He and Chris William Martin are the only two actors who appeared in both the first and the last episodes of Hillside (1990).
- Accompanied musician Alanis Morissette to the 2003 Canadian Juno Music Awards.
- Attended the World Celebrity Pro-Am golf tournament in Haikou, China. (October 2012)
- Shares his birthday, all but the year of birth, with Emilia Clarke.
- Son-in-law of Ernie Lively and Elaine Lively.
- Taylor Swift is godmother to daughter James whom Ryan had with Blake Lively.
- Former son-in-law of Karsten Johansson and Melanie Sloan.
- Former brother-in-law of Vanessa Johansson, Hunter Johansson, Adrian Johansson and Christian Johansson.
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