- Childhood friend of Mira Sorvino; they performed plays for the neighbors.
- Studied ballet as a teenager and participated in the Joffrey Ballet's summer programs. She began her stage career in earnest in Chicago, where she took over Madonna's role in the Chicago production of 'Speed the Plow', to great acclaim. She still does more stage work than film work, and she lives in New York.
- Graduate of Vassar College (1986).
- Was invited to join the Academy of Motion Picture Arts and Sciences (AMPAS) in June 2004.
- Studied under Uta Hagen at the HB Studio in the West Village in Manhattan.
- Partner of Jon Patrick Walker, their daughter Georgia was born in 2002.
- Auditioned for Baywatch (1989).
- First Daughter, Georgia, was born August 31, 2002; her second daughter, Mae, was born December 30, 2004.
- Mother is a retired school librarian.
- Nominated for the 2009 Tony Award for Best Performance for a Leading Actress in a Play for "God of Carnage".
- Played the wife of characters, played by Dermot Mulroney, in two movies: About Schmidt (2002) and The Family Tree (2011).
- Jeff Daniels, James Gandolfini, Marcia Gay Harden and she were awarded the 2012 Back Stage Garland Award for Ensemble for "God of Carnage" at the Ahmanson Theatre in Los Angeles, California.
- Has a 9-year-old wheaten terrier named Charlie.
- (Summer 2000) Currently starring on Broadway in Rebecca Gilman's Spinning Into Butter at Lincoln Center, to critical acclaim.
- Playing Mia on the HBO teleplay "In Treatment". (May 2009)
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