- (June 1, 2014) Her surrogate mother Delphine miscarried their future 2nd child while she was almost at 9 weeks of pregnancy.
- Moved to Los Angeles one week after getting her master's degree in Journalism. With two degrees under her belt, her first Hollywood job was working in the mail room for power agent Michael Ovitz, where she was paid minimum wage and delivered packages to stars like Leonardo DiCaprio and Martin Scorsese.
- Learned English by watching hours of news channels.
- Receive a bachelor's degree in journalism from the University of Maryland, College Park.
- On October 17, 2011 during an interview on Today (1952), Rancic announced she had been diagnosed with early stage breast cancer, for which she would be treated with a lumpectomy, followed by radiation. She underwent surgery in mid-October 2011 and returned to work at E! News about a week later. On December 5, 2011, Rancic disclosed she had decided to undergo a double mastectomy.
- She is also the founder of FabFitFun, a woman's health, beauty, and fashion site.
- Has two siblings; an older brother named Pasquale and a sister named Monica.
- Has a son, who had their embryo implanted into their gestational carrier, Edward Duke Rancic (b.August 29, 2012), with her husband Bill Rancic.
- Received a masters degree from the American University.
- Miscarried at 9 weeks of pregnancy, when she was pregnant with her and her husband Bill Rancic's 1st child. (September 2010)
- Hosted the Miss USA 2011 beauty pageant on NBC.
- Co-owner, with Bill Rancic, of restaurant "RPM Italian" in Chicago.
- Grew up in Washington DC.
- Good friends with Debbie Matenopoulos.
- Featured in People Magazine's 50 Most Beautiful of 2006 issue. Voted one of Maxim Magazine's Hot 100 of 2003.
- Engaged to Bill Rancic, former The Apprentice USA (2004) winner.
- Was married in Capri, Italy at Santa Sophia Church in Anacapri.
- Release of her book, "Think Like a Guy: How to Get a Guy by Thinking Like One". (June 2006)
- Attended Walt Whitman High School in Rockville, Maryland.
- Appeared, with Ben Stein and Shaquille O'Neal, in a commercial for the "Comcast Hollywood Triple Play". (2009)
- Introduced Lauren Scruggs to future husband, Jason Kennedy.
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