- After dubbing Jack Nicholson's voice in the Italian version of The Shining (1980), he received a telegram of congratulations from Stanley Kubrick.
- His great passion is inventing. Among other things, he invented the moving, playing jacket Robin Williams was wearing in Toys (1992).
- Italian dubbing voice of Jack Nicholson, Al Pacino, Michael Douglas, Gérard Depardieu, Dustin Hoffman and Ryan O'Neal.
- He was awarded a Star on the Hollywood Walk of Fame at 6361 Hollywood Boulevard in Hollywood, California on March 6, 2023. Producers Michael G. Wilson and Barbara Broccoli were guest speakers at the ceremony.
- In 2003, he was christened Grand Officer of the Order of Merit of the Italian Republic, Italy's highest civilian honor, for his services to the arts. In 2007, he was re-christened Knight Grand Cross of the Order of Merit of the Italian Republic.
- Has two sons with Livia Giampalmo: Lorenzo Giannini (1967-1987) and actor Adriano Giannini (born 1971). Has two sons with Eurilla del Bono: Emanuele Giannini and Francesco Giannini.
- Has played a police officer for both director Ridley Scott (Hannibal (2001)) and his brother Tony Scott (Man on Fire (2004)).
- Was among those offered for the role of Indiana Jones' archenemy Rene Belloq in Raiders of the Lost Ark (1981), which went to Paul Freeman.
- He was awarded a star on the Italian Walk of Fame in Toronto, Ontario in 2009.
- Fluent in Italian, English, French and Spanish.
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