- She took the role of the Baroness in G.I. Joe: The Rise of Cobra (2009) because it did not involve "having a breakdown, or addicted to heroin, or dying at the end; it was something that was just maybe really great fun".
- Her mother, Jo Miller, managed London's Lee Strasberg drama school.
- Rhys Ifans had to ask her three times to marry him before she finally said "yes".
- Replaced Emma Stone as Sally Bowles in the Broadway revival of "Cabaret", when Stone's contract expired. Miller had time in her schedule after the filming dates of The Lost City of Z (2016) was pushed back. The show marked the first time she sang professionally.
- Received an unprecedented $75,000 settlement when a British court ruled that British tabloids the "Sun" and the "News of the World" had violated her invasion of privacy rights. The tabloids had covertly photographed Miller doing a nude scene in the production Hippie Hippie Shake, and later published the pictures without prior permission (2007).
- Gave birth to her first child at age 30, a daughter Marlowe Ottoline Layng Sturridge on July 7, 2012. Child's father is her [now ex] fiancé, Tom Sturridge.
- Was engaged to Jude Law, having begun a relationship in October 2003 after meeting on the set of Alfie (2004) (December 2004-July 2005).
- She was born in the United States, but raised in the United Kingdom (although she spent several years as a teenager studying acting and modeling in New York City).
- Received a $162,000 settlement, in 2011, from News of the World's hacking of her phone.
- Was engaged to Tom Sturridge from January 2012 until July 2015, having begun a relationship in March 2011. They have one daughter together.
- In the summer of 2005, she made her West End debut in the stage production of William Shakespeare's "As You Like It", directed by David Lan, at the Wyndham Theatre. She played the role of Celia.
- Was five months pregnant with her daughter Marlowe when she completed filming A Case of You (2013). Was also nine months pregnant with Marlowe when she posed for a naked painting.
- Half-brother, Charles Miller, is a painter and maintains a studio in New York City.
- Had reconciled with Jude Law, following their initial break-up due to his affair with his children's nanny Daisy Wright (February-November 2006).
- Was engaged to Rhys Ifans, having been in a relationship with him since June 2007 (March-June 2008).
- Though New York-born, Miller grew up in southwest London's Parsons Green district.
- Attended and graduated from Heathfield School in Ascot, Berkshire, United Kingdom.
- Nominated for Outstanding Actress in the television movie The Girl (2012), at the 2012 Women's Image Network (WIN) Awards.
- She and co-star Hayden Christensen shared a house during the filming of Factory Girl (2006) in Louisiana.
- At The Oscars (2015), by coincidence, she presented the only Oscar that was awarded to her film American Sniper (2014), among the six nominations it was up for.
- Replaced Lindsay Lohan for the role of Caitlin MacNamarra in The Edge of Love (2008) starring alongside her close friend Keira Knightley.
- Returned to work three months after giving birth to her daughter Marlowe in order to begin filming Foxcatcher (2014).
- She was originally cast as Maid Marian in Robin Hood (2010) but the filmmakers then decided that she wasn't good enough alongside Russell Crowe so she was replaced by Cate Blanchett.
- She played the role of Catherine Greig in the crime drama Black Mass (2015), but director Scott Cooper decided to cut all her scenes due to "narrative choices".
- Had reconciled a second time with former fiancé Jude Law, having met again whilst appearing in separate stage productions in New York (October 2009-February 2011).
- Was in an on/off romance with Balthazar Getty (June 2008-April 2009).
- Is a huge fan of the sport golf and Chelsea FC (England football club).
- Friends with Chris Hemsworth and Elsa Pataky.
- On May 4, 2013, she was in attendance at the wedding of her The Edge of Love (2008) co-star Keira Knightley to James Righton.
- Launched, with her sister Savannah, her fashion line, which is named "Twenty8Twelve". Name refers to Sienna's birthday, which is December 28 (2007).
- Studied drama at the Lee Strasberg Institute in New York City.
- Ranked #2 in Ask men's top 99 "most desirable" women of 2006.
- During the making of G.I. Joe: The Rise of Cobra (2009), Sienna sprained her wrist and her co-star Rachel Nichols burned herself, while shooting the fight scene between Scarlett O'Hara and the Baroness.
- Named "Film Actress of the Year" at the 2007 Glamour Women of the Year Awards.
- Older sister, Savannah Miller, graduated from the prestigious Central Saint Martins College of Arts and Design.
- Her sister Savannah celebrates her birthday two days after Sienna's.
- Auditioned for the role of Kelly Jones in St. Trinian's (2007), but Gemma Arterton was cast instead.
- Ranked as having one of the "Most Beautiful Famous Faces" by "The Annual Independent Critics List of the 100 Most Beautiful Famous Faces From Around the World". She was ranked #21 in 2010, #13 in 2009, #10 in 2008, #8 in 2007, #2 in 2006, #13 in 2005, and #24 in 2004.
- On April 21, 2012, she was in attendance at the wedding of Carey Mulligan to Marcus Mumford.
- Named her two dogs Porgy and Bess, after the two leading characters in George Gershwin's opera of the same name.
- During her very first visit to Los Angeles at age 21, Sienna screen-tested with Ben Affleck for the role of Rachel Porter in Paycheck (2003). Unfortunately for her, the role went to Uma Thurman.
- Considers Madonna to be a close friend.
- She was considered for the role of Domino in the sequel Deadpool 2 (2018), but the role was given to Zazie Beetz.
- For more than a decade, her father, American banker Ed Miller, was married to top interior designer Kelly Hoppen.
- Ambassador for Global Cool.
- Sister Savannah is a designer and has her own label.
- Has a scar on her temple from a horse kick,.
- Ranked #48 on Maxim magazine's Hot 100 Women of 2005 list.
- Ranked #42 on Maxim magazine's Hot 100 Women of 2006 list.
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