- Adopted her professional name "Wilde" after she developed a profound respect and admiration for Irish poet and writer Oscar Wilde and his body of literature.
- When asked about the meaning behind the tattoo on her wrist, which says "All love, A", she explained "It's in honor of my late uncle Alexander Cockburn. He was a dear dear friend. The tattoo is the last phrase he wrote to me. All love, A. It reminds me to love everyone, just as he did.".
- Has dual originary citizenship between Ireland and the United States.
- Once won a pancake eating contest while in Australia.
- Mick Jagger was once her parents' dinner guest at their Washington, D.C. home and she had an impromptu brownie-eating contest with Chris Farley when at age 10, she visited the set of Saturday Night Live (1975).
- Named her son Otis Sudeikis after the late singer-songwriter Otis Redding, of whom she has been a huge fan since childhood.
- A lifelong lover of classic cars, she owns a 1958 Chevy Biscayne and a 1959 Thunderbird convertible. Once owned a 1966 Lincoln Continental.
- As a young girl, she was frequently babysat by British writer and family friend Christopher Hitchens.
- Her father was born in London, England, grew up in County Cork, Ireland, and became an Irish citizen. Her mother is American-born. Her father has English, Scottish, Northern Irish (Irish Protestant or Scottish-Irish), and 1/32 Sephardi Jewish, ancestry, while her mother has English, German, Irish, and Manx (Isle of Man) ancestry. Her Sephardi Jewish great-great-great-great-grandfather, Ralph Bernal-Osborne, was a British Whig politician who was also an actor. She is also a descendant of James IV of Scotland through his illegitimate daughter Margaret Stewart. She is also the 20th great-granddaughter of Daniel Bashta.
- Her well-connected journalist parents once helped her get a casting office job in Los Angeles, California, hoping the experience would dissuade her from taking up acting.
- Gave birth to her second child at age 32, daughter Daisy Sudeikis, on 10/11/16. Child's father is her now ex-fiancé, Jason Sudeikis.
- Her first job in Hollywood was as an assistant to casting director Mali Finn. She was cast by Finn in her first feature film, The Girl Next Door (2004). She spent one month on the set of the movie before being asked to join the movie's cast.
- She was considered for the role of Gamora in Guardians of the Galaxy (2014), which she turned down. Zoe Saldaña was cast instead. She was also considered for a role in Oz the Great and Powerful (2013).
- Has a dog named Paco who, as of 7/26/06, is the new mascot for Old Navy. Paco passed away on her 34th birthday on 3/10/18. She has another dog named Elvis.
- Replaced Kate Hudson for her role in the comedy film Butter (2011).
- She was rumored to play the lead Bond girl in Skyfall (2012).
- Was two months pregnant with her son Otis Sudeikis when she filmed her guest appearance on the comedy series Portlandia (2011). She returned to work two months after giving birth to her son to begin filming the period drama Vinyl (2016).
- Her Irish maiden name is actually pronounced "coh-burn".
- Ex-daughter-in-law of Dado Ruspoli, 9th Prince of Cerveteri and Debra Berger.
- She was included in FHM magazine's list of '100 Sexiest Women in the World' in 2010 (#18), 2011 (#5) and 2012 (#53); Maxim magazine's Hot 100 Women in 2009 (#1), 2010 (#20), 2011 (#15), 2012, (#5), 2013 (#16) and 2014 (#14); and AskMen's Top 99 Women of 2010 (#49), 2011 (#30), 2012 (#23) and 2013 (#54).
- Has been a major fan of the "Star Trek" franchise since childhood.
- Granddaughter of Patricia Cockburn and Francis Claud Cockburn, who used the pen name Claud Cockburn.
- Attended Georgetown Day School in Washington, D.C., through 8th grade.
- Niece of Alexander Cockburn, Patrick Cockburn and Sarah Caudwell.
- Was in a relationship with singer Harry Styles (January 2021-November 2022).
- Fifth cousin of actress Rose Leslie through Scottish nobility.
- Ex-sister-in-law of Bartolomeo Ruspoli and Aileen Getty.
- She eloped with her high school boyfriend Tao Ruspoli, and they were married on a school bus in Washington, Virginia when she was age 18.
- From 2011-2016, she was the brand ambassador for the cosmetics company Revlon.
- She resided on a school bus after first moving to Los Angeles, California.
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