- Daughter of Andie MacDowell, an actress and model, and Paul Qualley, a rancher, model, contractor, and musician.
- Made her fashion debut at the age of 16, modeling for Italian fashion designer Alberta Ferretti.
- She has appeared in three films that have been nominated for the Best Picture Oscar: Once Upon a Time... in Hollywood (2019), Poor Things (2023) and The Substance (2024).
- Younger sister of Rainey Qualley and Justin Qualley.
- On May 31, 2022. Qualley announced her engagement to Jack Antonoff.
- Invited to join the Actors Branch of AMPAS in 2025.
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