While apparently set in Seattle, filming is mostly done in Los Angeles. The fire-station's exterior establishing shots are from the Seattle Fire Department's actual Station 20 (there is no real-world 'Station 19'), located on 15th Avenue West on Queen Anne's west side.
Maya Bishop has a gold medal from the women's 10,000 meters at the 2012 Olympics in London. In real life, that medal was won by Tirunesh Dibaba of Ethiopia.
Before starring in Station 19 and its parent show Grey's Anatomy in 2018 as Pruitt Herrera, Miguel Sandoval appeared in a 2012 episode of Grey's Anatomy as Hank, the partner of a patient undergoing a liver transplant.
Jay Hayden (Travis) and Jaina Lee Ortiz (Andy) are dating in real life