This is the only one of Ray Harryhausen's films to be shot in anamorphic widescreen (2.35:1) due to the higher cost of anamorphic camera and projection lenses needed for his Dynamation Process.
In the book, the large monster which the Selenites hunt is called a Mooncalf. This is an old English term for idiot, since it was believed that being out under a full moon could cause madness (think also "lunatic"), but is also a clever pun on H.G. Wells' part, as the Selenites also hunt this beast like cattle, the young of which is called a calf.
William Rushton was originally supposed to play the bailiff's man in the film, but he was taken ill on the morning he was due to do his one brief scene. Peter Finch, who was working on an adjoining soundstage on The Pumpkin Eater (1964), replaced him at the last minute.
Selenites were played by cockney street kids.
Composer Bernard Herrmann, who created the music scores for Charles H. Schneer and Ray Harryhausen's previous four films, was originally considered to compose the music score for this film, but he asked for a bigger salary, and because Schneer and Harryhausen's films were low-budget, they, unfortunately, could not meet his price, therefore, Laurie Johnson was chosen instead.
Peter Finch: as the bailiff's man, around 0:43:43. He was reputedly only visiting the set when the original actor assigned to play the part failed to show up.