The giant lobster was built in one and a half weeks by cast member Vincent Peranio, who would go on to a career as a film production designer. It cost about thirty-seven dollars to make.
The film had its first opening in a rented out church basement in Baltimore.
The re-mastered Criterion version of Multiple Maniacs has had some songs replaced/substituted. The Elvis Presley songs "Jailhouse Rock" and "Just Because" have been taken out and replaced by similar pieces by George S. Clinton, as has the music on the opening credits.
The original ending was supposed to link Divine to the Charles Manson murders, but when it was discovered that the Manson family was responsible, the ending was changed to what it is in the final film. The original ending would have fed the publicity gag that Divine was responsible for Sharon Tate's murder.
"Lobstora" was inspired by a postcard Waters had of the beach at Provincetown, Massachusetts with a big lobster in the sky.
John Waters: [manson] Lady Divine constantly taunts Mr. David with the idea that he is responsible for the Manson murders.
John Waters: [Catholicism] The Infant of Prague appears to and assists Lady Divine, and a sequence takes place in a Catholic church.