During an interview for the PBS series "Pioneers of Television," Noah Wyle said that while filming some of Carter's Africa storyline in the Kalahari Desert, the real on-set medic passed out from the heat, and Wyle (who by that time had been filmed pretending to perform hundreds of simulated medical procedures for the television show) inserted a real I.V. and hooked the medic up to a real saline drip.
Although mostly shot at "Warner Brothers" Burbank soundstages, the cast and crew usually would make at least two trips to Chicago each season to shoot realistic exterior scenes for several episodes, which include many familiar Chicago landmarks. These scenes are typically shot on early Sunday mornings to avoid disrupting traffic.
Goran Visnjic named his character after the writers could not develop an appropriately Croatian name. The character is named for Visnjic's nephew (Luka) and his best friend (Kovac).
If anything had gone wrong during the live episode broadcast, such as a technical failure or forgotten dialogue, the producers had additional actors ready to improvise a scene that would have been inserted to cover. This contingency was never used.
Anthony Edwards was the first choice to play the part of Dr. Mark Greene. Unfortunately, Edwards was committed to directing a feature film when he couldn't film the pilot. By sheer luck, his feature was pushed back, and he was able to film the pilot instead.