The creators said that the four crossover chapters were inspired by the trailers for the original movie, which showed Stitch appearing in other Disney films.
The only voice actors to not reprise their roles from Lilo & Stitch (2002) in the tv spinoff are Jason Scott Lee as David Kawena, Ving Rhames as Cobra Bubbles (although he did do so in the show's pilot and finale films), and Miranda Paige Walls as Mertle Edmonds.
In Spring 2004, Disney Channel ran a poll asking viewers to vote for the Top 10 favorite experiments and episodes. They were:
- 10: Experiment 360: Drowsy
- 9: Experiment 608: Slugger
- 8: Experiment 323: Hunkahunka
- 7: Experiments 501 & 502: Yin and Yang
- 6: Experiment 158: Finder
- 5: Experiment 627
- 4: Experiment 300: Spooky
- 3: Experiment 254: Mr. Stenchy
- 2: Experiment 151: Babyfier
- 1: Experiment 624: Angel
Pleakley is the character with the most look changes within the series and perhaps all the animated Disney series. He has used more than 24 outfits and 16 types of wigs in the series.