In chapter 11, once you watch the cutscenes (after leaving the tower), you can obtain a trophy called "Stage Fright" by standing still for 30 seconds. This is a humorous reference to Naughty Dogs technical problems when they first showed the scene on a live stage demo at E3.
Laura Bailey auditioned for and won the role of Nadine prior to the finalization of the character design. A concept artist later drew a piece of art with Nadine as a black character and director Neil Druckmann liked the idea of Nadine being a black character but feared inviting controversy having a white actress voice and perform a black character. It wasn't until Naughty Dog had seen Bailey's performance in context that they decided to keep Nadine as a black character as it "vanished into the part and you didn't see anything but Nadine".
Sold over 2.7 million copies during its first week of release.
First major Uncharted game not to include Greg Edmonson as the main composer for the game. Also first Uncharted game not to include the Original Nate's Theme or any song on the main menu. New composer Henry Jackman made a new version of the Nate's Theme, keeping a few pieces from the original score mixed with the new "Pirate feeling" score. The song is called A Thief's End.
There are three "Strange Relics" that can be found in the game, each referencing Naughty Dog's three other Playstation game series. The Strange Pendant is a Firefly pendant from The Last of Us, the Strange Relic is a precursor orb from Jak and Daxter, and the Strange Fruit is a wumpa fruit from Crash Bandicoot.