MX1

Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene.^[5][6]

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MX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LJB, 3SZR, 3ZYS, 4P4S, 4P4T, 4P4U
Identifiers
Aliases	MX1, IFI-78K, IFI78, MX, MxA, MX dynamin like GTPase 1, lncMX1-215
External IDs	OMIM: 147150; MGI: 97244; HomoloGene: 1844; GeneCards: MX1; OMA:MX1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 41,420,020 bp[1] End 41,470,071 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 C4|16 57.51 cM Start 97,336,508 bp[2] End 97,362,100 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trigeminal ganglion spinal ganglia nasal epithelium palpebral conjunctiva monocyte decidua olfactory zone of nasal mucosa granulocyte spleen human penis Top expressed in embryo surface ectoderm duodenum thymus choroid plexus of fourth ventricle yolk sac muscle of thigh liver islet of Langerhans perirhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding GTPase activity microtubule binding identical protein binding Cellular component cytoplasm cytosol nuclear membrane endoplasmic reticulum membrane membrane endoplasmic reticulum perinuclear region of cytoplasm nucleus mitochondrial membranes Biological process defense response immune system process response to virus type I interferon signaling pathway innate immune response signal transduction apoptotic process response to type I interferon negative regulation of viral genome replication mitochondrial fission dynamin family protein polymerization involved in mitochondrial fission membrane fusion defense response to virus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4599 17858 Ensembl ENSG00000157601 ENSMUSG00000023341 UniProt P20591 Q9WVP9 RefSeq (mRNA) NM_001144925 NM_001178046 NM_001282920 NM_002462 NM_013606 RefSeq (protein) NP_001138397 NP_001171517 NP_001269849 NP_002453 NP_038634 Location (UCSC) Chr 21: 41.42 – 41.47 Mb Chr 16: 97.34 – 97.36 Mb PubMed search [3] [4]
Wikidata
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In mice, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. Furthermore, the human orthologue MxA is a major host determinant for influenza viruses of animal origin.^[7] The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin superfamily and the family of large GTPases.^[6]