NKX2-2

Homeobox protein Nkx-2.2 is a protein that in humans is encoded by the NKX2-2 gene.^[5][6][7]

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NKX2-2
Identifiers
Aliases	NKX2-2, NKX2.2, NKX2B, NK2 homeobox 2
External IDs	OMIM: 604612; MGI: 97347; HomoloGene: 1879; GeneCards: NKX2-2; OMA:NKX2-2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p11.22 Start 21,511,017 bp[1] End 21,514,064 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 G2|2 72.63 cM Start 147,177,546 bp[2] End 147,194,243 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior ganglion of vagus nerve subthalamic nucleus Medulla Oblongata superior vestibular nucleus ventral tegmental area inferior olivary nucleus spinal cord C1 segment external globus pallidus pars reticulata Top expressed in islet of Langerhans lumbar subsegment of spinal cord optic nerve central gray substance of midbrain ventral nucleus of lateral geniculate body embryo anterior horn of spinal cord nucleus of stria terminalis Hypothalamus cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding DNA-binding transcription factor activity transcription factor binding chromatin binding transcription coactivator activity cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component intracellular anatomical structure nucleoplasm nucleus Biological process positive regulation of oligodendrocyte differentiation cell differentiation regulation of transcription, DNA-templated negative regulation of neuron differentiation pancreatic PP cell fate commitment response to organic cyclic compound cell development spinal cord oligodendrocyte cell fate specification response to progesterone neuron fate specification response to glucose transcription, DNA-templated nervous system development multicellular organism development brain development astrocyte differentiation positive regulation of gene expression positive regulation of neuron differentiation positive regulation of cell differentiation regulation of cell differentiation smoothened signaling pathway oligodendrocyte development spinal cord motor neuron differentiation digestive tract development pancreatic A cell fate commitment type B pancreatic cell fate commitment ventral spinal cord interneuron fate determination type B pancreatic cell development spinal cord oligodendrocyte cell differentiation optic nerve development positive regulation of transcription by RNA polymerase II positive regulation of DNA-binding transcription factor activity endocrine pancreas development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4821 18088 Ensembl ENSG00000125820 ENSMUSG00000027434 UniProt O95096 P42586 RefSeq (mRNA) NM_002509 NM_001077632 NM_010919 RefSeq (protein) NP_002500 NP_001071100 NP_035049 Location (UCSC) Chr 20: 21.51 – 21.51 Mb Chr 2: 147.18 – 147.19 Mb PubMed search [3] [4]
Wikidata
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Homeobox protein Nkx-2.2 contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.^[7]

The expression of Nkx2-2 is regulated by an antisense RNA called Nkx2-2as.^[8]

In the developing spinal cord, Nkx-2.2 regulates IRX3 thereby contributing to the proper differentiation of the ventral horn neurons.^[9]