OSBPL5

Oxysterol-binding protein-related protein 5 is a protein that in humans is encoded by the OSBPL5 gene.^[5]

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OSBPL5
Identifiers
Aliases	OSBPL5, OBPH1, ORP5, oxysterol binding protein like 5
External IDs	OMIM: 606733; MGI: 1930265; HomoloGene: 98024; GeneCards: OSBPL5; OMA:OSBPL5 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 3,087,107 bp[1] End 3,166,739 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F5|7 88.29 cM Start 143,242,499 bp[2] End 143,310,722 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell tendon of biceps brachii canal of the cervix granulocyte sural nerve ectocervix popliteal artery tibial arteries thoracic aorta Descending thoracic aorta Top expressed in Ileal epithelium corneal stroma sciatic nerve lip ankle joint decidua superior surface of tongue plantaris muscle cardiac muscle tissue of left ventricle esophagus More reference expression data BioGPS n/a
Gene ontology Molecular function cholesterol binding phosphatidylinositol-4-phosphate binding oxysterol binding phosphatidylserine binding lipid binding phospholipid transporter activity sterol transporter activity sterol binding Cellular component integral component of membrane endoplasmic reticulum membrane membrane endoplasmic reticulum cytosol intracellular membrane-bounded organelle endoplasmic reticulum-plasma membrane contact site Biological process phospholipid transport cholesterol transport lipid transport cholesterol metabolic process Golgi to plasma membrane transport phosphatidylserine acyl-chain remodeling transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114879 79196 Ensembl ENSG00000021762 ENSMUSG00000037606 UniProt Q9H0X9 Q9ER64 RefSeq (mRNA) NM_001144063 NM_020896 NM_145638 NM_001199227 NM_024289 NM_001384163 RefSeq (protein) NP_001137535 NP_065947 NP_663613 NP_001186156 NP_077251 NP_001371092 Location (UCSC) Chr 11: 3.09 – 3.17 Mb Chr 7: 143.24 – 143.31 Mb PubMed search [3] [4]
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This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified.^[5]