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ARHGEF9

Protein-coding gene in humans From Wikipedia, the free encyclopedia

ARHGEF9

Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ARHGEF9 gene.[5][6][7]

Quick Facts Available structures, PDB ...
ARHGEF9
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARHGEF9, COLLYBISTIN, EIEE8, HPEM-2, PEM-2, PEM2, Cdc42 guanine nucleotide exchange factor 9, DEE8
External IDsOMIM: 300429; MGI: 2442233; HomoloGene: 9053; GeneCards: ARHGEF9; OMA:ARHGEF9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001033329
NM_001290384
NM_001290385

RefSeq (protein)
Location (UCSC)Chr X: 63.63 – 63.81 MbChr X: 94.09 – 94.24 Mb
PubMed search[3][4]
Wikidata
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Function

ARHGEF9 belongs to a family of Rho-like GTPases that act as molecular switches by cycling from the active GTP-bound state to the inactive GDP-bound state. These proteins are key regulators of the actin cytoskeleton and are involved in cell signaling.[supplied by OMIM][7]

Interactions

ARHGEF9 has been shown to interact with GPHN[8] and SMURF1.[9]

References

Further reading

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