Alpha-actinin-1

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha-actinin-1 is an F-actin cross-linking protein – a bundling protein that is thought to anchor actin to a number of intracellular structures.^[6] Alpha-actinin-1 is a non-muscle cytoskeletal isoform found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.^[7]

Alpha-actinin-1 has been shown to interact with:

• CDK5R1,^[8]
• CDK5R2,^[8]
• Collagen, type XVII, alpha 1,^[9]
• GIPC1,^[10]
• PDLIM1,^[11][12]
• Protein kinase N1,^[13]
• SSX2IP,^[14] and
• Zyxin.^[15][16]
• PTPRT (PTPrho)^[17]

• Actinin