BAIAP3

BAI1-associated protein 3 is a protein that in humans is encoded by the BAIAP3 gene.^[5][6]

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BAIAP3
Identifiers
Aliases	BAIAP3, BAP3, BAI1 associated protein 3
External IDs	OMIM: 604009; MGI: 2685783; HomoloGene: 20844; GeneCards: BAIAP3; OMA:BAIAP3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 1,333,638 bp[1] End 1,349,441 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 25,461,633 bp[2] End 25,475,338 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube anterior pituitary right frontal lobe Brodmann area 9 cingulate gyrus anterior cingulate cortex Hypothalamus Amygdala olfactory zone of nasal mucosa prefrontal cortex Top expressed in arcuate nucleus ventromedial nucleus dorsomedial hypothalamic nucleus median eminence paraventricular nucleus of hypothalamus suprachiasmatic nucleus lateral hypothalamus nucleus of stria terminalis central gray substance of midbrain ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function syntaxin binding SNARE binding calcium ion binding protein binding phospholipid binding Cellular component presynapse endoplasmic reticulum dense core granule early endosome membrane cytosol plasma membrane late endosome membrane trans-Golgi network membrane recycling endosome membrane cytoplasm endosome Golgi apparatus membrane Biological process G protein-coupled receptor signaling pathway dense core granule maturation positive regulation of neurotransmitter secretion regulation of synaptic transmission, GABAergic positive regulation of insulin secretion involved in cellular response to glucose stimulus retrograde transport, endosome to Golgi regulation of dense core granule exocytosis exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8938 545192 Ensembl ENSG00000007516 ENSMUSG00000047507 UniProt O94812 Q80TT2 RefSeq (mRNA) NM_001199096 NM_001199097 NM_001199098 NM_001199099 NM_001286464 NM_003933 NM_001163270 RefSeq (protein) NP_001186025 NP_001186026 NP_001186027 NP_001186028 NP_001273393 NP_003924 n/a Location (UCSC) Chr 16: 1.33 – 1.35 Mb Chr 17: 25.46 – 25.48 Mb PubMed search [3] [4]
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BAIAP3 was identified as a protein-binding partner of BAI1. BAI1 is a p53-target gene that encodes a brain-specific angiogenesis inhibitor. The protein is a seven-span transmembrane protein and a member of the secretin receptor family. BAIAP3 interacts with the cytoplasmic region of brain-specific angiogenesis inhibitor 1. BAIAP3 also contains two C2 domains, which are often found in proteins involved in signal transduction or membrane trafficking. Its expression pattern and similarity to other proteins suggest that it may be involved in synaptic functions.^[6]