CENTD3

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 is a protein that in humans is encoded by the ARAP3 gene.^[5][6][7]

Quick Facts ARAP3, Available structures ...

ARAP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KG5, 2LNW, 5JD0, 5JCP
Identifiers
Aliases	ARAP3, CENTD3, DRAG1, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
External IDs	OMIM: 606647; MGI: 2147274; HomoloGene: 11199; GeneCards: ARAP3; OMA:ARAP3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.3 Start 141,653,401 bp[1] End 141,682,230 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B3 Start 38,105,681 bp[2] End 38,132,022 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right lung blood upper lobe of left lung tendon of biceps brachii left ventricle canal of the cervix right auricle subcutaneous adipose tissue ventricular zone Top expressed in granulocyte tail of embryo yolk sac genital tubercle muscle of thigh esophagus zygote embryo right kidney lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding phosphatidylinositol-3,4-bisphosphate binding protein binding GTPase activator activity phosphatidylinositol-3,4,5-trisphosphate binding Cellular component cytosol cell projection membrane plasma membrane cytoskeleton lamellipodium ruffle cytoplasm Biological process positive regulation of GTPase activity negative regulation of Rac protein signal transduction cytoskeleton organization regulation of small GTPase mediated signal transduction vesicle-mediated transport signal transduction negative regulation of cell migration negative regulation of Rho protein signal transduction regulation of cell shape Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64411 106952 Ensembl ENSG00000120318 ENSMUSG00000024451 UniProt Q8WWN8 Q8R5G7 RefSeq (mRNA) NM_022481 NM_001205336 NM_139206 RefSeq (protein) NP_071926 NP_001192265 NP_631945 Location (UCSC) Chr 5: 141.65 – 141.68 Mb Chr 18: 38.11 – 38.13 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its full-length nature has not been determined.^[7]