POU4F3

POU domain, class 4, transcription factor 3 is a protein that in humans is encoded by the POU4F3 gene.^[5][6] It's a member of BRN-3 group, also known as POU family class 4.

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POU4F3
Identifiers
Aliases	POU4F3, BRN3C, DFNA15, POU class 4 homeobox 3, DFNA42, DFNA52
External IDs	OMIM: 602460; MGI: 102523; HomoloGene: 2023; GeneCards: POU4F3; OMA:POU4F3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q32 Start 146,338,839 bp[1] End 146,341,728 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 B3|18 22.58 cM Start 42,527,604 bp[2] End 42,530,314 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in smooth muscle tissue tibial arteries islet of Langerhans C1 segment Top expressed in lumbar spinal ganglion organ of Corti embryo vestibular sensory epithelium neural layer of retina otolith organ utricle saccule basal plate lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm nucleus cytoplasm Biological process regulation of transcription, DNA-templated hearing inner ear development visual perception transcription by RNA polymerase II transcription, DNA-templated cell differentiation positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II vestibulocochlear nerve development retinal ganglion cell axon guidance inner ear morphogenesis inner ear auditory receptor cell differentiation axon extension neuromuscular process controlling balance neuron apoptotic process inner ear receptor cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5459 18998 Ensembl ENSG00000091010 ENSMUSG00000024497 UniProt Q15319 Q63955 RefSeq (mRNA) NM_002700 NM_138945 RefSeq (protein) NP_002691 NP_620395 Location (UCSC) Chr 5: 146.34 – 146.34 Mb Chr 18: 42.53 – 42.53 Mb PubMed search [3] [4]
Wikidata
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