PROP1

Homeobox protein prophet of PIT-1 is a protein that in humans is encoded by the PROP1 gene.^[5][6]

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PROP1
Identifiers
Aliases	PROP1, CPHD2, PROP-1, PROP paired-like homeobox 1
External IDs	OMIM: 601538; MGI: 109330; HomoloGene: 4558; GeneCards: PROP1; OMA:PROP1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.3 Start 177,992,235 bp[1] End 177,996,242 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B1.3|11 30.95 cM Start 50,841,633 bp[2] End 50,844,592 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Pituitary Gland anterior pituitary Top expressed in anterior pituitary Rathke's pouch embryo pars distalis of adenohypophysis blastocyst lumbar spinal ganglion digastric muscle lumbar subsegment of spinal cord carotid body spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding beta-catenin binding chromatin binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein C-terminus binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription regulator complex nucleus Biological process regulation of transcription, DNA-templated somatotropin secreting cell differentiation hypothalamus cell differentiation hypophysis morphogenesis negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II adenohypophysis development central nervous system development blood vessel development animal organ morphogenesis canonical Wnt signaling pathway dorsal/ventral pattern formation cell migration positive regulation of transcription by RNA polymerase II gland development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5626 19127 Ensembl ENSG00000280635 ENSG00000175325 ENSG00000274382 ENSMUSG00000044542 UniProt O75360 P97458 RefSeq (mRNA) NM_006261 NM_008936 RefSeq (protein) NP_006252 NP_032962 Location (UCSC) Chr 5: 177.99 – 178 Mb Chr 11: 50.84 – 50.84 Mb PubMed search [3] [4]
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PROP1 has both DNA-binding and transcriptional activation ability. Its expression leads to ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes, and caudomedial thyrotropes. Inactivating mutations in PROP1 result in deficiencies of luteinizing hormone (LH; MIM 152780), follicle-stimulating hormone (FSH; MIM 136530), growth hormone (GH; MIM 139250), prolactin (PRL; MIM 176760), and thyroid-stimulating hormone (TSH; MIM 188540). See combined pituitary hormone deficiency (CPHD; MIM 262600).[supplied by OMIM]^[6]