SB-334867

SB-334867 is an orexin antagonist. It was the first non-peptide antagonist developed that is selective for the orexin receptor subtype OX₁, with around 50x selectivity for OX₁ over OX₂ receptors.^[1] It has been shown to produce sedative and anorectic effects in animals,^[2] and has been useful in characterising the orexinergic regulation of brain systems involved with appetite and sleep,^{[3][4][5][6][7][8]} as well as other physiological processes.^{[9][10][11][12]} The hydrochloride salt of SB-334867 has been demonstrated to be hydrolytically unstable, both in solution and as the solid.^[13] Orexin antagonists have multiple potential clinical applications including the treatment of drug addiction, insomnia, obesity and diabetes.^{[14][15][16][17][18][19][20][21]}

Quick Facts Identifiers, CAS Number ...

SB-334867

Identifiers
IUPAC name 1-(2-methylbenzoxazol-6-yl)-3-[1,5]naphthyridin-4-yl urea
CAS Number	249889-64-3 N
PubChem CID	6604926
IUPHAR/BPS	1703
ChemSpider	5037182 Y
ChEMBL	ChEMBL291536 Y
CompTox Dashboard (EPA)	DTXSID901356447 DTXSID10947856, DTXSID901356447
ECHA InfoCard	100.164.490
Chemical and physical data
Formula	C17H13N5O2
Molar mass	319.324 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(Nc1c2ncccc2ncc1)Nc3ccc4nc(oc4c3)C
InChI InChI=1S/C17H13N5O2/c1-10-20-12-5-4-11(9-15(12)24-10)21-17(23)22-14-6-8-18-13-3-2-7-19-16(13)14/h2-9H,1H3,(H2,18,21,22,23) Y Key:AKMNUCBQGHFICM-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

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