SNX3

Sorting nexin-3 is a protein that in humans is encoded by the SNX3 gene.^[5][6]

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SNX3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YPS, 2MXC
Identifiers
Aliases	SNX3, Grd19, MCOPS8, SDP3, sorting nexin 3
External IDs	OMIM: 605930; MGI: 1860188; HomoloGene: 36144; GeneCards: SNX3; OMA:SNX3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q21 Start 108,211,222 bp[1] End 108,261,246 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 B2|10 22.89 cM Start 42,378,026 bp[2] End 42,411,377 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trabecular bone middle temporal gyrus visceral pleura parietal pleura endothelial cell right ventricle germinal epithelium parotid gland Epithelium of choroid plexus Brodmann area 23 Top expressed in lactiferous gland CA3 field pyloric antrum yolk sac fetal liver hematopoietic progenitor cell calvaria plantaris muscle facial motor nucleus perirhinal cortex entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol-3-phosphate binding phosphatidylinositol-3,5-bisphosphate binding phosphatidylinositol-4-phosphate binding phosphatidylinositol-5-phosphate binding protein binding phosphatidylinositol binding protein phosphatase binding lipid binding phosphatidylinositol phosphate binding Cellular component cytoplasm cytosol endosome early endosome membrane early phagosome retromer complex early endosome phagocytic vesicle extracellular exosome cytoplasmic vesicle clathrin-coated vesicle extrinsic component of membrane endosome membrane Biological process protein to membrane docking negative regulation of viral entry into host cell negative regulation of phagocytosis response to bacterium negative regulation of protein catabolic process negative regulation of early endosome to late endosome transport membrane invagination regulation of Wnt signaling pathway intralumenal vesicle formation negative regulation of protein transport positive regulation of neuron projection development protein transport Wnt signaling pathway protein deubiquitination transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8724 54198 Ensembl ENSG00000112335 ENSMUSG00000019804 UniProt O60493 O70492 RefSeq (mRNA) NM_152828 NM_001300928 NM_001300929 NM_003795 NM_152827 NM_017472 RefSeq (protein) NP_001287857 NP_001287858 NP_003786 NP_690040 n/a Location (UCSC) Chr 6: 108.21 – 108.26 Mb Chr 10: 42.38 – 42.41 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking.^[6]