Toponomics
Study of protein networks in biology From Wikipedia, the free encyclopedia
Toponomics is a discipline in systems biology, molecular cell biology, and histology concerning the study of the toponome of organisms.[1][2] It is the field of study that purposes to decode the complete toponome in health and disease (the human toponome project)[3]—which is the next big challenge in human biotechnology after having decoded the human genome.[3][4]
A toponome is the spatial network code of proteins and other biomolecules in morphologically intact cells and tissues.[2][5]
The spatial organization of biomolecules in cells is directly revealed by imaging cycler microscopy with parameter- and dimension-unlimited functional resolution. The resulting toponome structures are hierarchically organized and can be described by a three symbol code.[1][5][6][7]
Etymology
The terms toponome and toponomics were introduced in 2003 by Walter Schubert based on observations with imaging cycler microscopes (ICM).[1]
Toponome derived from the ancient Greek nouns topos (τόπος, 'place, position') and 'nomos' (νόμος, 'law'). Hence toponomics is a descriptive term addressing the fact that the spatial network of biomolecules in cells follows topological rules enabling coordinated actions.[1]
References
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