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YWHAQ

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

YWHAQ

14-3-3 protein theta is a protein that in humans is encoded by the YWHAQ gene.[4]

Quick Facts Available structures, PDB ...
YWHAQ
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesYWHAQ, 14-3-3, 1C5, HS1, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
External IDsOMIM: 609009; MGI: 3650241; HomoloGene: 105677; GeneCards: YWHAQ; OMA:YWHAQ - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006826

n/a

RefSeq (protein)

NP_006817

n/a

Location (UCSC)Chr 2: 9.58 – 9.63 Mbn/a
PubMed search[2][3]
Wikidata
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Function

This gene product belongs to the 14-3-3 family of proteins that mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence that is polymorphic; however, there is no correlation between the repeat number and the disease.[5]

Interactions

YWHAQ has been shown to interact with:

References

Further reading

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