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Obviously syntactic validation could be done at the level of RDF tools.
Previous discussion on use of shex/shacl for defining shapes: #30
OWL reasoning (potentially incorporating SWRL) is another possibility
But note that any implementation should be scalable to large genomes
Related discussion on GFF3 validation tools: The-Sequence-Ontology/Specifications#18 (these have proven vital for large genome projects, but unfortunately there is fragmentation in their implementation)
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