diff --git a/github/repos_lfs.go b/github/repos_lfs.go
new file mode 100644
index 00000000000..6ac2e5a8778
--- /dev/null
+++ b/github/repos_lfs.go
@@ -0,0 +1,49 @@
+// Copyright 2022 The go-github AUTHORS. All rights reserved.
+//
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+
+package github
+
+import (
+	"context"
+	"fmt"
+)
+
+// EnableLFS turns the LFS (Large File Storage) feature ON for the selected repo.
+//
+// GitHub API docs: https://docs.github.com/en/rest/repos/lfs#enable-git-lfs-for-a-repository
+func (s *RepositoriesService) EnableLFS(ctx context.Context, owner, repo string) (*Response, error) {
+	u := fmt.Sprintf("repos/%v/%v/lfs", owner, repo)
+
+	req, err := s.client.NewRequest("PUT", u, nil)
+	if err != nil {
+		return nil, err
+	}
+
+	resp, err := s.client.Do(ctx, req, nil)
+	if err != nil {
+		return resp, err
+	}
+
+	return resp, nil
+}
+
+// DisableLFS turns the LFS (Large File Storage) feature OFF for the selected repo.
+//
+// GitHub API docs: https://docs.github.com/en/rest/repos/lfs#disable-git-lfs-for-a-repository
+func (s *RepositoriesService) DisableLFS(ctx context.Context, owner, repo string) (*Response, error) {
+	u := fmt.Sprintf("repos/%v/%v/lfs", owner, repo)
+
+	req, err := s.client.NewRequest("DELETE", u, nil)
+	if err != nil {
+		return nil, err
+	}
+
+	resp, err := s.client.Do(ctx, req, nil)
+	if err != nil {
+		return resp, err
+	}
+
+	return resp, nil
+}
diff --git a/github/repos_lfs_test.go b/github/repos_lfs_test.go
new file mode 100644
index 00000000000..f171b6e36af
--- /dev/null
+++ b/github/repos_lfs_test.go
@@ -0,0 +1,64 @@
+// Copyright 2022 The go-github AUTHORS. All rights reserved.
+//
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+
+package github
+
+import (
+	"context"
+	"net/http"
+	"testing"
+)
+
+func TestRepositoriesService_EnableLFS(t *testing.T) {
+	client, mux, _, teardown := setup()
+	defer teardown()
+
+	mux.HandleFunc("/repos/o/r/lfs", func(w http.ResponseWriter, r *http.Request) {
+		testMethod(t, r, "PUT")
+
+		w.WriteHeader(http.StatusNoContent)
+	})
+
+	ctx := context.Background()
+	if _, err := client.Repositories.EnableLFS(ctx, "o", "r"); err != nil {
+		t.Errorf("Repositories.EnableLFS returned error: %v", err)
+	}
+
+	const methodName = "EnableLFS"
+	testBadOptions(t, methodName, func() (err error) {
+		_, err = client.Repositories.EnableLFS(ctx, "\n", "\n")
+		return err
+	})
+
+	testNewRequestAndDoFailure(t, methodName, client, func() (*Response, error) {
+		return client.Repositories.EnableLFS(ctx, "o", "r")
+	})
+}
+
+func TestRepositoriesService_DisableLFS(t *testing.T) {
+	client, mux, _, teardown := setup()
+	defer teardown()
+
+	mux.HandleFunc("/repos/o/r/lfs", func(w http.ResponseWriter, r *http.Request) {
+		testMethod(t, r, "DELETE")
+
+		w.WriteHeader(http.StatusNoContent)
+	})
+
+	ctx := context.Background()
+	if _, err := client.Repositories.DisableLFS(ctx, "o", "r"); err != nil {
+		t.Errorf("Repositories.DisableLFS returned error: %v", err)
+	}
+
+	const methodName = "DisableLFS"
+	testBadOptions(t, methodName, func() (err error) {
+		_, err = client.Repositories.DisableLFS(ctx, "\n", "\n")
+		return err
+	})
+
+	testNewRequestAndDoFailure(t, methodName, client, func() (*Response, error) {
+		return client.Repositories.DisableLFS(ctx, "o", "r")
+	})
+}