diff --git a/homeassistant/components/mqtt/manifest.json b/homeassistant/components/mqtt/manifest.json
index c5d9ad21ed614..6fb81deeb4d9f 100644
--- a/homeassistant/components/mqtt/manifest.json
+++ b/homeassistant/components/mqtt/manifest.json
@@ -3,7 +3,7 @@
   "name": "MQTT",
   "config_flow": true,
   "documentation": "https://www.home-assistant.io/integrations/mqtt",
-  "requirements": ["paho-mqtt==1.5.1"],
+  "requirements": ["paho-mqtt==1.6.1"],
   "dependencies": ["http"],
   "codeowners": ["@emontnemery"],
   "iot_class": "local_push"
diff --git a/homeassistant/components/shiftr/manifest.json b/homeassistant/components/shiftr/manifest.json
index f7f04eb5a8663..fc475c2f48efa 100644
--- a/homeassistant/components/shiftr/manifest.json
+++ b/homeassistant/components/shiftr/manifest.json
@@ -2,7 +2,7 @@
   "domain": "shiftr",
   "name": "shiftr.io",
   "documentation": "https://www.home-assistant.io/integrations/shiftr",
-  "requirements": ["paho-mqtt==1.5.1"],
+  "requirements": ["paho-mqtt==1.6.1"],
   "codeowners": ["@fabaff"],
   "iot_class": "cloud_push"
 }
diff --git a/homeassistant/package_constraints.txt b/homeassistant/package_constraints.txt
index 32a75ef29d02c..e845eb9884782 100644
--- a/homeassistant/package_constraints.txt
+++ b/homeassistant/package_constraints.txt
@@ -19,7 +19,7 @@ home-assistant-frontend==20211103.0
 httpx==0.19.0
 ifaddr==0.1.7
 jinja2==3.0.2
-paho-mqtt==1.5.1
+paho-mqtt==1.6.1
 pillow==8.2.0
 pip>=8.0.3,<20.3
 pyserial==3.5
diff --git a/requirements_all.txt b/requirements_all.txt
index 5be24b230932a..d98b7e2dbb073 100644
--- a/requirements_all.txt
+++ b/requirements_all.txt
@@ -1169,7 +1169,7 @@ p1monitor==1.0.0
 
 # homeassistant.components.mqtt
 # homeassistant.components.shiftr
-paho-mqtt==1.5.1
+paho-mqtt==1.6.1
 
 # homeassistant.components.panasonic_bluray
 panacotta==0.1
diff --git a/requirements_test_all.txt b/requirements_test_all.txt
index cb32a187e9227..db71f65a9ab07 100644
--- a/requirements_test_all.txt
+++ b/requirements_test_all.txt
@@ -695,7 +695,7 @@ p1monitor==1.0.0
 
 # homeassistant.components.mqtt
 # homeassistant.components.shiftr
-paho-mqtt==1.5.1
+paho-mqtt==1.6.1
 
 # homeassistant.components.panasonic_viera
 panasonic_viera==0.3.6