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Fig. 3 | Applied Microbiology and Biotechnology

Fig. 3

From: Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation

Fig. 3

Biosynthesis of PIM. Each circle represents an enzymatic domain. ACP acyl carrier protein, AT acyltransferase, CoL carboxylic acid:CoA ligase, DH ß-hydroxyacyl-thioester dehydratase, KR ß-ketoacyl-ACP reductase, KS ß-ketoacyl-ACP synthase, and TE thioesterase. The KR domain in black (module 9) is predicted to be inactive. The AT in module 7 (grey) is predicted to incorporate a propionate extender unit. Biosynthetic pathway for mycosamine is also included. The isomerisation step is thought to be spontaneous

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