The NCCN Soft Tissue Sarcoma Guidelines include a subsection about treatment
recommendations for gastrointestinal stromal tumors (GISTs). The standard of practice rapidly …

… Pappo AS, Crist WM, Kuttesch J, et al. Tumor-cell DNA content predicts outcome in
children and adolescents with Clinical Group III embryonal rhabdomyosarcoma. J Clin Oncol …

PURPOSE To review key developments in biology and therapy of rhabdomyosarcoma (RMS)
since the early 1970s. PATIENTS AND METHODS The literature regarding biology, therapy…

Background Fusions involving one of three tropomyosin receptor kinases (TRK) occur in
diverse cancers in children and adults. We evaluated the efficacy and safety of larotrectinib, a …

Heparan sulfate proteoglycans interact with many extracellular matrix constituents, growth
factors and enzymes. Degradation of heparan sulfate by endoglycosidic heparanase …

Background The prevalence and spectrum of predisposing mutations among children and
adolescents with cancer are largely unknown. Knowledge of such mutations may improve the …

The new method has proved to be successful with some simple mono- and di-substituted
olefins. With the permanganate-catalyzed reaction such olefins generally give an aldehyde …

Background The selective TRK inhibitor larotrectinib was approved for paediatric and adult
patients with advanced TRK fusion-positive solid tumours based on a primary analysis set of …

Pediatric osteosarcoma is characterized by multiple somatic chromosomal lesions, including
structural variations (SVs) and copy number alterations (CNAs). To define the landscape of …

The Michael condensation in its original scope is the addition of an addend or donor containing
an alpha‐hydrogen atom in the system OCCH to a carbon‐carbon double bond that …