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Cancer cell line proteomic map

License: GPL v3

Description

Graphical_abstract

Pan-cancer proteomic map of 949 human cell lines. Goncalves, Poulos & Cai, et al 2022

A collaboration beteen CMRI ProCan & Sanger GDSC.

Raw data processing

Raw mass spectrometry (MS) data were processed with DIA-NN - see associated publication for details. Code for generating final protein data matrices from the DIA-NN output is found under the "Raw_data_processing" subfolder.

Major analyses

Code relating to major analyses found in the associated publication are documented in labelled subfolders in this repository. For example, the exploratory_analysis subfolder contains basic statistical analysis, dimensionality reduction analysis and differential analysis of the proteomic dataset. The machine_learning subfolder contains the code for deep learning and benchmarking related analysis.

The README file in each subfolder contains a list that summarises the figures associated with the code in that subfolder for easy navigation.

Contact

For more information, please contact the study authors. Contact details are available in the associated publication.

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CMRI ProCan & Sanger GDSC cancer cell lines SWATH proteomics

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