Heterogeneity and clinical significance of sex hormone levels in testis carcinoma
The analysis pursues thee goals:
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differences between two main histological types of testicle cancer: seminoma and non-seminomatous germ cell tumors (NSGCT)
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characteristic, co-regulation and phenotyping by serum levels of sex hormones prior to the cancer surgery
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prognostic significance of pre-surgery sex hormone levels for relapse-free survival
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investigation of expression of sex hormone-related genes in testicle cancer tissue from the TCGA cohort and its implication for tumor biology, immunity, signaling and prognosis
These tasks are addressed in a multicenter retrospective cohort of 518 testis cancer patients and the testis cancer collactive of the TCGA pan-cancer project (n = 149).
You may follow the analysis progress here. In particular
In particular, the analysis report figures as high-resolution pdf files are available here.
The latest version of the analysis report is available from Dropbox.
Parts of the Testicular Cancer manuscript with analyses of the retrospective cohort (Figures, Tables, Supplement) are available [here](https://github.com/PiotrTymoszuk/TesCa_hormones/tree/main/tesca%20paper).
To reference and use analysis results, please cite our GitHub repository and our publication (DOI: 10.1038/s41598-023-41915-7). In any questions or requests of the Innsbruck cohort data, please contact Renate Pichler or Piotr Tymoszuk.
To make sure to install required development packages prior to runung the pipeline:
devtools::install_github('PiotrTymoszuk/ExDA')
devtools::install_github('PiotrTymoszuk/kmOptimizer')
devtools::install_github('PiotrTymoszuk/coxExtensions')
devtools::install_github('PiotrTymoszuk/trafo')
devtools::install_github('PiotrTymoszuk/clustTools')
devtools::install_github('PiotrTymoszuk/soucer')
devtools::install_github('PiotrTymoszuk/figur')
devtools::install_github('PiotrTymoszuk/caretExtra')
To launch the entire pipeline, source the exec.R file:
source('exec.R')
The maintainer of the repository is Piotr Tymoszuk.