Please note that this reposity is not actively maintained and is achived. Please check out the active celltalker repository at CilloLaboratory/celltalker.
The goal of celltalker is to infer putative ligand and receptor interactions from single-cell RNAseq data. This is accomplished by evaluating known cognate ligand/receptor interactions across groups of cells. Interactions are scored by jointly weighting the expression levels of ligands and receptors, and significance is evaluated by comparing to a background distribution of scrambled ligands and receptors.