The goal of the acmgscaler R package is to provide a robust approach for gene-level calibration of variant effect scores, such as computational predictions or functional assay results, against ACMG/AMP evidence thresholds.
The package is lightweight and written entirely in base R, without additional dependencies.
A plug-and-play Google Colab notebook with a simple interface is available for all users.
You can install the development version of acmgscaler directly from GitHub using the devtools package:
# install devtools if you haven't already
install.packages('devtools')
# install the acmgscaler package from GitHub
devtools::install_github('badonyi/acmgscaler')If you find this package useful, refer to Badonyi & Marsh, bioRxiv (2025); doi: 10.1101/2025.05.16.654507v1