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ibd-gwas

Pediatric IBD (late and early onset) vs healthy

Questions

  • Can adult IBD associatons be used for a pediatric polygenic risk score?
  • Does grouping adult IBD associatons by pathway improve pediatric polygenic risk score?

Run:

conda create env create -f envs/project.yml

before imputation

snakemake -s Snakefile.py --use-singularity --singularity-args "-B /mnt/isilon/:/mnt/isilon" --use-conda -j22 before_imputation

impute with https://imputationserver.sph.umich.edu/index.html w/ data/iterim/eur_vcf/*vcf.gz and download imputed files to data/interim/imputed/

run after imputation

snakemake -s Snakefile.py --use-singularity --singularity-args "-B /mnt/isilon/:/mnt/isilon" --use-conda -j22 after_imputation

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